Boeing 757-200 fuel burn averages 0.36‑0.52 mpg, about 80.7 passenger‑mile per gallon

A fully loaded Boeing 757‑200 achieves roughly 0.36 miles per gallon on paper, while lighter operating weights improve efficiency to about 0.52 miles per gallon, according to Simple Flying.

The aircraft consumes approximately 1,020 US gallons of jet fuel per hour at Mach 0.80 cruise speed, which translates to about 80.7 passenger miles per gallon when divided across 200 occupied seats.